I-labelled radioligands. A comparison between different imaging systems and data acquisition protocols using Monte Carlo simulation
نویسندگان
چکیده
Purpose I-labelled radioligands are commonly used for single-photon emission computed tomography (SPECT) imaging of the dopaminergic system to study the dopamine transporter binding. The aim of this work was to compare the quantitative capabilities of two different SPECT systems through Monte Carlo (MC) simulation. Methods The SimSET MC code was employed to generate simulated projections of a numerical phantom for two gamma cameras equipped with a parallel and a fan-beam collimator, respectively. A fully 3D iterative reconstruction algorithm was used to compensate for attenuation, the spatially variant point spread function (PSF) and scatter. A post-reconstruction partial volume effect (PVE) compensation was also developed. Results For both systems, the correction for all degradations and PVE compensation resulted in recovery factors of the theoretical specific uptake ratio (SUR) close to 100%. For a SUR value of 4, the recovered SUR for the parallel imaging system was 33% for a reconstruction without corrections (OSEM), 45% for a reconstruction with attenuation correction (OSEM-A), 56% for a 3D reconstruction with attenuation and PSF corrections (OSEM-AP), 68% for OSEM-AP with scatter correction (OSEM-APS) and 97% for OSEM-APS plus PVE compensation (OSEM-APSV). For the fan-beam imaging system, the recovered SUR was 41% without Eur J Nucl Med Mol Imaging (2008) 35:1334–1342 DOI 10.1007/s00259-007-0711-z C. Crespo :A. Cot :C. Falcón : P. Aguiar :D. Ros (*) Unitat de Biofísica i Bioenginyeria, Departament de Ciències Fisiològiques I, Facultat de Medicina, Universitat de Barcelona—IDIBAPS, Casanova 143, 08036 Barcelona, Spain e-mail: [email protected] J. Gallego : J. Sempau : F. Calviño Institut de Tècniques Energètiques, Universitat Politècnica de Catalunya, Barcelona, Spain J. Gallego Institut de Bioenginyeria de Catalunya, Barcelona, Spain A. Cot : F. Calviño Secció d’Enginyeria Nuclear, Departament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya, Barcelona, Spain C. Falcón :D. Pareto : J. Sempau : J. Pavía :D. Ros CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain S. Bullich Center for Imaging in Psychiatry, CRC-MAR, Hospital del Mar, Barcelona, Spain D. Pareto Institut d’Alta Tecnologia, PRBB, Barcelona, Spain F. Lomeña : J. Pavía Servei de Medicina Nuclear, Hospital Clínic, IDIBAPS, Barcelona, Spain corrections, 55% for OSEM-A, 65% for OSEM-AP, 75% for OSEM-APS and 102% for OSEM-APSV. Conclusion Our findings indicate that the correction for degradations increases the quantification accuracy, with PVE compensation playing a major role in the SUR quantification. The proposed methodology allows us to reach similar SUR values for different SPECT systems, thereby allowing a reliable standardisation in multicentric studies.
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